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高恩军

  

  个人简历:

  高恩军,理学博士,药学博士后,博士生导师。辽宁省化学会副理事长,国务院政府特殊津贴获得者,辽宁省优秀专家,辽宁特聘教授(首批、滚动支持),二级教授,辽宁科技大学博士生导师、辽宁大学博士生导师、东北师范大学兼职教授。现任辽宁科技大学工程材料化学研究院院长,担任沈阳市政协常委、九三学社沈阳市委员会副主任委员等职务。曾就职于沈阳化工大学,任学科发展规划处处长、研究生学院院长、化学工程学院院长等职务。

  1982/09 — 1986/07 辽宁大学                            学士

  1986/09 — 1989/06 中国科学院长春应用化学研究所               硕士

  1999/09 — 2003/12 东北师范大学                          博士

  2004/03 — 2007/03 沈阳药科大学      药学博士后流动站        博士后

  主要研究方向、成果及获奖情况:

  一、主要研究方向

  1. 分子多样性与超分子化学:研究金属-有机配体构筑的配位化合物的晶体结构及超分子聚集体的拓扑关系;

  2. 无机材料与无机药物化学:研究微孔、介孔及微纳米无机材料的制备工艺与应用。研究基于临床顺铂修饰衍生物对肿瘤细胞的抑制活性及其靶向DNA作用机理;

  3. 石墨烯先进复合材料的创制:研究石墨烯的制备工艺与性能参数,石墨烯定向复合导电导热膜材料先进工艺;

  4. MOF材料的合成与性能:研究长链有机芳香配体与过渡或镧系金属离子构筑的MOF孔洞材料,用于药物载体、水解产氢催化剂、有机污染物的降解与高灵敏检测等领域。

  成果:

  二、主持的重要科研项目

  1. 主持在研“多手性中心精细化工中间体的精准制备及新型催化技术”项目,国家自然科学科学基金-辽宁联合基金重点项目,80万元, 2017.1-2022.12;

  2. 主持在研“基于H.Sigel溶液中弱作用的晶体分子构筑与性能研究”项目,国家自然科学基金面上项目,65万元, 2017.01-2020.12;

  3. 主持在研“MOF功能材料的制备与性能研究”项目,辽宁特聘教授滚动支持计划,100万元,2018.01-2020.12;

  4. 主持在研“石墨烯功能材料的定向创制技术与产业化”项目,校企合作,30万元,2018.09-2021.08;

  5. 主持在研“高附加值镁精细化工系列产品先进技术及其产业化”项目,科技部,16万元,2019.05-;

  6. 主持完成“刚性和柔性配体协同调控钯、铂配合物的结构调控及细胞毒性”,国家自然科学基金面上项目,60万元,2012.01-2015.12;

  7, 主持完成“从分子夹到超分子的配位化学及生物化学基础”,国家自然科学基金面上项目,33万元,2010.01-2012.12;

  8, 主持完成“脂肪链调控钯配合物的结构及其生物活性”,国家自然科学基金面上项目,30万元,2007.01-2009.12;

  9, 主持完成“由稻米糠提取菲叮技术研究”,科技部上合组织合作项目,2015.01-2017.12

  10, 主持完成“超分子结构与水簇拓扑关系”,辽宁特聘教授首批支持计划,100万元,2011.01-2014.12。

  三、获奖成果

  1. 高品质多功能碳酸镁氧化镁环保节能生产新工艺,辽宁省科技进步二等奖(2018年度);

  2. 分子的调控机制与性能,辽宁省自然科学三等奖(2017年度);

  3. 金属-有机配体构筑的晶体分子多样性及其在药学领域中的应用,辽宁省自然科学二等奖(2015年度);

  4. 配合物中配体间的弱相互作用及其生物活性,辽宁省自然科学三等奖(2006年度);

  5. 螯合型三元配合物稳定性、抗癌活性及其与DNA作用研究,辽宁省自然科学三等奖(2002年度)。

  四、代表性论文(仅列JCR一区、影响因子3.0以上的论文)

  (1). MC Zhu, JX Liu, JQ Su, B Meng, YH Feng, B Jia, TT Peng, ZZ Qi, EJ Gao*. Two MnII, CuII complexes derived from 3,5-bis(1-imidazoly) pyridine: Synthesis, DNA binding, Molecular docking and cytotoxicity studies. Applied Organometallic Chemistry, 33(1)(2019), e4676.

  (2). EJ Gao*, JL Xing, Y Qu, X Qiu, MC Zhu. Synthesis, characterization, DNA binding, cytotoxicity and molecular docking properties of Cu (II) and Mn (II) complexes with 1,4-bis (pyrazol-1-yl) terephthalic acid. Applied Organometallic Chemistry, 32(10)(2018).

  (3). MC Zhu, N Wang, B Meng, JQ Su, TT Peng, ZZ Qi, B Jia, YH Feng, EJ Gao*. Two Ho(III) and Co(II) complexes constructed from bis(triazol-1-yl)benzoic acid with structurally similar carboxyl ligands: Syntheses, structures and biological activities. Applied Organometallic Chemistry, 32(12)(2018), e4571.

  (4). MC Zhu, TT Peng, N Sun, X Qiu, Y Zhan, YQ Ding, SZ Zhang, EJ Gao*. A series of novel complexes firstly constructed by 1,4-phenylenedioxydiacetic acid plays a role in disruption of DNA gene expression and induction of apoptosis. Journal of Inorganic Biochemistry, 180(2018): 141-154.

  (5). EJ Gao*, YH Feng, JQ Su, B Meng, B Jia, ZZ Qi, TT Peng, MC Zhu. Synthesis, characterization, DNA binding, apoptosis and molecular docking of three Mn(II), Zn(II) and Cu(II) complexes with terpyridine-based carboxylic acid. Applied Organometallic Chemistry, 32(3)(2018).

  (6). EJ Gao*, ZZ Qi, Y Qu, YQ Ding, Y Zhan, N Sun, SZ Zhang, X Qiu, MC Zhu. Two novel dinuclear ellipsoid Ni(II) and Co(II) complexes bridged by 4,5-bis(pyrazol-1-yl)phthalic acid: Synthesis, structural characterization and biological evaluation. European Journal of Medicinal Chemistry, 136(2017): 235-245.

  (7). EJ Gao*, YQ Ding, N Sun, SZ Zhang, X Qiu, Y Zhan, MC Zhu. Synthesis, characterization, DNA interaction, apoptosis and molecular docking of Cu(II) and Mn(II) complexes with endo-norbornene-cis-5,6-dicarboxylic acid. Applied Organometallic Chemistry, 31(3)(2017).

  (8). EJ Gao*, N Sun, SZ Zhang, YQ Ding, X Qiu, Y Zhan, MC Zhu, Synthesis, structures, molecular docking, cytotoxicity and bioimaging studies of two novel Zn(II) complexes, European Journal of Medicinal Chemistry, 121 (2016) 1-11.

  (9). MC Zhu, XT Cui, SZ Zhang, L Liu, ZB Han*, EJ Gao*. The structures, cytotoxicity, apoptosis and molecular docking controlled by the aliphatic chain of palladium(II) complexes. Journal of Inorganic Biochemistry, 157(2016): 34-45.

  (10). MC Zhu, XT Cui, SZ Zhang, L Liu, ZB Han, EJ Gao*, The structures, cytotoxicity, apoptosis and molecular docking controlled by the aliphatic chain of palladium(II) complexes, Journal of Inorganic Biochemistry, 157 (2016) 34-45.

  (11). LF Li, H Wang, J Zhang, C Ma, YY Li, L Wang, SK Liang, HT Jin, SJ Liu, MC Zhu, E.J. Gao*, Syntheses, characterization, interaction with DNA, cytotoxic and apoptosis of two novel complexes of Zn(II) and Mn(II) with 2-methyl-1H-4,5-imidazoledicarboxylic acid, European Journal of Medicinal Chemistry, 92 (2015) 295-301.

  (12). EJ Gao*, H Fu, MC Zhu, C Ma, SK Liang, J Zhang, LF Li, L Wang, YY Li, W Jiao, Effect of carbon chain length on biological activity of novel palladium (II) complexes, European Journal of Medicinal Chemistry, 82 (2014) 172-180.

  (13). YG Sun*, D Sun, W Yu, MC Zhu, F Ding, YN Liu, EJ Gao*, SJ Wang, G Xiong, I Dragutan, V Dragutan, Synthesis, characterization, interaction with DNA and cytotoxicity of Pd(II) and Pt( II) complexes containing pyridine carboxylic acid ligands, Dalton Transactions, 42 (2013) 3957-3967.

  (14). EJ Gao*, L Lin, L Liu, MC Zhu, B Wang, XA Gao, Two new palladium( II) complexes: synthesis, characterization and their interaction with HeLa cells, Dalton Transactions, 41 (2012) 11187-11194.

  (15). EJ Gao*, F Guan, XN Gao, MC Zhu, L Liu, CS Wang, WZ Zhang, YG Sun, Novel palladium(II) complexes containing a sulfur ligand: structure and biological activity on HeLa cells, Journal of Biological Inorganic Chemistry, 17 (2012) 263-274.

  (16). MC Zhu, WX He, L Lin, Y Zhang, L Dai, RS Wang, B Wang, ML Wang, EJ Gao*. Synthesis, characterization, and cytotoxicity in vitro of the complex Mn (Hptc) (phen) (OH) n. Life Sciences, 90(13-14)(2012): 519-524.

  (17). MC Zhu, L Dai, L Lin, B Wang, L Liu, EJ Gao*. Synthesis, characterization and cytotoxicity of a carboxylic ligand 2,2-bis(3-phenylpropyl) malonic acid and a corresponding Mn(II) complex. Dalton Transactions, 41(43)(2012): 13352-13358.

  (18). MC Zhu, WX He, EJ Gao*, L Lin, Y Zhang, L Dai, RS Wang, B Wang, ML Wang, Synthesis, characterization, and cytotoxicity in vitro of the complex Mn (Hptc) (phen) (OH) n, Life Sciences, 90 (2012) 519-524.

  (19). MC Zhu, L Dai, EJ Gao*, L Lin, B Wang, L Liu, Synthesis, characterization and cytotoxicity of a carboxylic ligand 2,2-bis(3-phenylpropyl) malonic acid and a corresponding Mn(II) complex, Dalton Transactions, 41 (2012) 13352-13358.

  (20). YG Sun*, G Xiong, MY Guo, F Ding, SJ Wang, PF Smet, D Poelman, EJ Gao*, F Verpoort, Hydrothermal synthesis, crystal structure and properties of Ni(II)-4f complexes based on 1H-benzimidazole-5,6-dicarboxylic acid, Dalton Transactions, 41 (2012) 7670-7680.

  (21). EJ Gao*, L Liu, MC Zhu, Y Huang, F Guan, XN Gao, M Zhang, L Wang, WZ Zhang, YG Sun, Synthesis, Characterization, Interaction with DNA, and Cytotoxic Effect in Vitro of New Mono- and Dinuclear Pd(II) and Pt(II) Complexes with Benzo d thiazol-2-amine As the Primary Ligand, Inorganic Chemistry, 50 (2011) 4732-4741.

  (22). EJ Gao*, L Lin, Y Zhang, RS Wang, MC Zhu, SH Liu, TD Sun, W Jiao, VZ Andrey, Synthesis, characterization, and study on HeLa cells activity of a dinuclear complex Cu-4(phen)(4)(H2O)(2) center dot(pyri)center dot 3H(2)O, European Journal of Medicinal Chemistry, 46 (2011) 2546-2554.

  (23). EJ Gao*, XN Gao, F Guan, MC Zhu, L Liu, M Zhang, YX Zhang, Y Wang, Z.Wen, Y Zhang, Y Zhang, Q Hang, Synthesis and crystal structure of two new dinuclear cobalt(II) complexes interaction with HeLa cells, European Journal of Medicinal Chemistry, 46 (2011) 160-167.

  (24). YG Sun*, B Jiang, TF Cui, G Xiong, PF Smet, F Ding, EJ Gao, TY Lv, K Van den Eeckhout, D Poelman, F Verpoort, Solvothermal synthesis, crystal structure, and properties of lanthanide-organic frameworks based on thiophene-2,5-dicarboxylic acid, Dalton Transactions, 40 (2011) 11581-11590.

  (25). EJ Gao*, MC Zhu, Y Huang, L Liu, HY Liu, FC Liu, S Ma, CY Shi, New pH-dependent complexes, from mononuclear Pd(II) monomer to heteronuclear Pd(II),K(I) Polymer: DNA cleavage and cytotoxicity in vitro, European Journal of Medicinal Chemistry, 45 (2010) 1034-1041.

  (26). EJ Gao*, L Wang, MC Zhu, L Liu, WZ Zhang, Synthesis, characterization, interaction with DNA and cytotoxicity in vitro of the complexes M(dmphen)(CO3) center dot H2O M = Pt(II), Pd(II), European Journal of Medicinal Chemistry, 45 (2010) 311-316.

  (27). EJ Gao*, KH Wang, MC Zhu, L Liu, Hairpin-shaped tetranuclear palladium(II) complex: Synthesis, crystal structure, DNA binding and cytotoxicity activity studies, European Journal of Medicinal Chemistry, 45 (2010) 2784-2790.

  (28). EJ. Gao*, TD. Sun, SH Liu, SA Ma, Z Wen, Y Wang, MC Zhu, L Wang, XN Gao, F Guan, MJ Guo, FC Liu, Synthesis, characterization, interaction with DNA and cytotoxicity in vitro of novel pyridine complexes with Zn(II), European Journal of Medicinal Chemistry, 45 (2010) 4531-4538.

  (29). EJ Gao*, MC Zhu, HX Yin, L Liu, Q Wu, YG Sun, Synthesis, characterization, interaction with DNA and cytotoxicity in vitro of dinuclear Pd(II) and Pt(II) complexes dibridged by 2,2 '-azanediyldibenzoic acid, Journal of Inorganic Biochemistry, 102 (2008) 1958-1964.

  (30). EJ Gao*, KH Wang, XF Gu, Y Yu, YG Sun, WZ Zhang, HX Yin, Q Wu, MC Zhu, XM Yan, A novel binuclear palladium complex with benzothiazole-2-thiolate: Synthesis, crystal structure and interaction with DNA, Journal of Inorganic Biochemistry, 101 (2007) 1404-1409.